This prescription lowered the cost of amoxicillin more than double

Amoxicillin belongs to the penicillin class of antibiotics. Because it is cheap, low drug residues or no residues, it has an advantage in terms of economic value and food safety. However, who konws amoxicillin powder well all know that this drug has a high drug resistance rate for gram-negative bacteria such as Escherichia coli, Pasteurella and Salmonella, which are common in livestock and poultry.

In order to solve the problem of high resistance rate of single amoxicillin soluble powder, so later veterinary drug R&D and manufacturers developed: amoxicillin plus synergist "potassium clavulanate" to compose compound amoxicillin powder. In this way, the strong broad-spectrum resistance of potassium clavulanate solves the problem of resistance to amoxicillin soluble powder.

However, compound amoxicillin powder, while solving the problem of drug resistance of unilateral amoxicillin soluble powder, also brings a new problem: it is much more expensive than unilateral amoxicillin soluble powder! As a result, this inhibits the use on the vet medicine of livestock and poultry , resulting in its use in livestock and poultry clinic for so many years is not very large.

So, is there a way to dramatically reduce the therapeutic cost of compound amoxicillin while ensuring that it is highly sensitive and highly effective? Of course, it is necessary to use the advantages of high sensitivity and high efficiency of compound amoxicillin through the prescription technology of drug compounding, while taking advantage of the medium and high sensitivity but extremely cheap advantages of amoxicillin colistin sulfate soluble powder and enrofloxacin hydrochloride.

Then, the prescription since then has been: the compound amoxicillin powder product containing the broad spectrum of highly effective synergist "potassium clavulanate", and amoxicillin colistin sulfate soluble powder and Enrofloxacin hydrochloride soluble powder, according to the special ratio and dosage of "prescription use". In this way, the cost of compound amoxicillin powder can be reduced by at least more than double.

At the same time, it ensures the high sensitivity and high efficiency of the antibacterial, and also expands the antibacterial spectrum to "improve the effectiveness of treatment". This formulation/prescribing technology, when combined with the corresponding symptomatic treatment drugs, it will make the prescription more effective in treating the specific disease infection. Therefore, a low-cost prescription that can be effectively treated must have a treatment idea that combines the cause and the symptom.

First, combined application of amoxicillin and compound amoxicillin:

Amoxicillin soluble powder has low toxicity, low residue and low cost. It is widely used in veterinary clinic. However, amoxicillin resistance is high, and it is inactivated by β-endacylase, so that its use effect is reduced. Compound amoxicillin is amoxicillin: clavulanate potassium =4:1 ratio mixed to overcome bacterial resistance caused by B-lactamase. For paraswine, pleuropneumonia, streptococcus prominent effect. Ordinary amoxicillin is less effective.
The ratio of amoxicillin to potassium clavulanate in foreign compound amoxicillin powder is 7:1, while our ratio is 4:1. According to studies, the synergistic effect of compound amoxicillin in the body can be as low as 20:1, and there is a synergistic effect. Therefore, in order to reduce the use cost of compound amoxicillin and make it play a good role in clinical practice, it is recommended to use compound amoxicillin powder and unilateral amoxicillin soluble powder 1:2 ratio. The effect of clinical use has been well played, hope to learn from.

Second, the combined application of amoxicillin soluble powder and carbapyrine calcium soluble powder
Calcium metabolites of carbapyrine (salicylic acid) competitively inhibit penicillins in glomerular filtration and renal tubule secretion, thereby delaying drug excretion. Therefore, the combination of carbapyrine calcium and penicillins (ampicillin, amoxicillin) can improve the efficacy of the latter.

Third, the advantages of amoxicillin + colistin sulfate combination

The combination of amoxicillin is beneficial to the stability of molecular structure, and the antibacterial spectrum is complementary, which greatly expands the antibacterial spectrum. Third, the two are compatible and have a significant synergistic effect. Pharmacopeia standards have amoxicillin - colistin sulfate suspension, so powder recommended the compatibility of the two.

Summary: In order to make the clinical application effect of amoxicillin more significant, Wudang Animal Protection hereby recommends the combination of amoxicillin and compound amoxicillin, the combination of carbapyrine calcium and colistin.

Clinical experience sharing of efficient application of amoxicillin:

In clinical farmers often use 10% amoxicillin 1-2 kg mix 1 ton or 10% compound amoxicillin 1 kg mix 1 ton, the therapeutic dose is low. In order to save costs, to achieve the purpose of efficiency. Can use compound amoxicillin 1 kg + unilateral 10% amoxicillin 1-2 kg +50% carbapyrine calcium 0.5 kg +5% colistin sulfate 1 kg mix or drinking water 1 ton.

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Clinical application notes of compound amoxicillin powder and ordinary amoxicillin powder

Amoxicillin is easily hydrolyzed in water, and drinking water needs to be consumed within 2 hours. The mix is relatively stable and can be maintained for 1 week.

Compound amoxicillin is more unstable than amoxicillin, especially when used in mixes, which need to be used the same day because potassium clavulanate is very easily oxidized. More recommended drinking water medication, 2 hours after drinking water.