The mechanism of action of vitamin K2is similar to vitamin K1. K vitamins were first recognized as a factor required for coagulation, but the functions performed by this vitamin group were revealed to be much more complex. K vitamins play an essential role as cofactor for the enzyme γ-glutamyl carboxylase, which is involved in vitamin K-dependent carboxylation of thegla domainin "Gla proteins" (i.e., in conversion of peptide-boundglutamic acid(Glu) to γ-carboxy glutamic acid (Gla) in these proteins).
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