Characteristics and application of calcium carbapyrine, antipyretic analgesic for animals

Most farmers know that carbaprim calcium is fever, but it seems that in addition to fever, other functions are ignored, when used on the breeding site, it is not too clear, the technician lets use, it is used, sometimes looking at the chicken spirit is not good, in the end kaba in which scenarios, the best use? Here to tell you about the main effects of carbapyrine calcium and use scenarios.

Carpapil calcium is one of the few antipyretic, analgesic, anti-inflammatory and antiendotoxin drugs approved by the Ministry of Agriculture and Rural Affairs for use in food animals. Calcium carbapyrine is a derivative of "aspirin" (acetylsalicylic acid), a complex of calcium acetylsalicylate and urea, chemically called bis-one (2-acetyloxybenzoic acid) urea. It has rapid oral absorption, rapid effect and high bioavailability. Compared with most antipyretic drugs, it has stronger antipyretic and analgesic effect, less adverse reactions, almost no stimulating effect on gastrointestinal mucosa, and there is no withdrawal period.

Effect of calcium carbapyrine on pigs

1, carbapyrine calcium can reduce fever and will not reduce to normal body temperature below, anti-inflammatory to reduce the inflammation of the pig itself, relieve pain.

2, when a large group of pigs, such as foot-and-mouth disease, swine fever, influenza, blue ear disease, etc., can not be injected one by one, and foot-and-mouth disease injection is likely to myocarditis injury pigs; Therefore, it is very convenient to drink with carbapyrine calcium, and other drugs are more troublesome to drink mashed water.

3, for the leg and hoof disease pig effect is also very good, because the pig inflammation will hurt the leg, carbaprim calcium can reduce inflammation and pain, so it is also a very good choice.

4, some diseases of low-grade fever, such as cough and wheeze or mycotoxins, use carbapyrine calcium mix on the line, this will be more convenient; We drink water only when the pigs are not eating.

5, the addition of carbapyrine calcium in drinking water can effectively alleviate the symptoms of fever and joint pain brought by influenza to pigs, and then combined with antiviral Chinese medicines such as Yinqiao powder, Qingkailing, Qingwen disinfectant powder and amoxicillin mix, generally about five days can be recovered. Even if the epidemic prevention is not in place in the pig farm with low antibody titer, carbapyrine combined with drug treatment for about 10 days can effectively control the disease.

The specific use of carbapyrine calcium

1, carbapyrine calcium generally add 50% carbapyrine calcium 250-500 grams per ton of drinking water.

2, the initial dosage is slightly larger, two days before the onset of the disease to add 500 grams per ton of water, after three days to add 250 grams per ton of water for five days, can play a good role

Effect of calcium carbapyrine on poultry

Carbapyrine calcium can currently be used alone or in combination with other drugs in chicken and duck farming under the following conditions.

1, chicken and duck simple cold: runny nose, elongated eyes, lying lazy, feathers reverse standing and other manifestations, can be used with mycoplasma drugs, quickly eliminate symptoms.

2. When poultry has viral diseases: when infectious bronchitis, influenza, Newcastle disease, infectious bursitis and other viral diseases occur, use this product to relieve the symptoms of fever and pain, reduce the high fever and cold expression of chickens, and enhance the activity of chickens.

3, reduce metabolic renal edema: When disease occurs in chickens, all kinds of toxins are excreted through the kidney, causing kidney swelling, or due to virus damage to the kidney resulting in urate deposition, the use of this product can remove urate, relieve renal edema.

4, anti-inflammation with antibiotics: When there is inflammation such as sacositis, colibacillosis, serositis and other antibiotics need to be treated with antibiotics, this product can reduce tissue inflammatory exudation, auxiliary antibiotics play a stronger effect.

Incompatibility of caraprim calcium

1, carbapyrine calcium should be avoided with glucocorticoid drugs such as dexamethasone, prednisone, etc., because the combination of the two will reduce the resistance of the animal's stomach and duodenal mucosa to stomach acid, and aggravate gastrointestinal bleeding.

2, because the metabolite of aspirin salicylic acid is acidic, and the use of alkaline drugs will reduce the efficacy of the drug, we must pay attention to the compatibility, to avoid unnecessary losses caused by improper use of drugs.

3. Carbapyrine calcium and antibiotics such as penicillin, amoxicillin, cephalosporin, gentamicin, etc.; Or with antiviral drugs isatis root, Astragalus polysaccharide, echinacea and other commonly used plant drugs can be used.

The difference between calcium carbapyrine and other antipyretic drugs

1, anti-inflammatory effect: carbapyrine calcium has anti-inflammatory effect, anemone, paracetamol, aspirin do not.

2, in terms of water solubility: carbapyrine calcium and acetaminophen are easily soluble in water, aspirin is insoluble in water, paracetamol is slightly soluble in water.

3. Side effects: carbaprim calcium has no side effects at all, while aspirin can easily lead to gastrointestinal ulcer and bleeding; The side effect of anemone is large, it can cause immunosuppression; Paracetamol has fewer side effects.

Carbapyrine calcium can enhance the effect of doxycycline, why can't it be mixed together for drinking water?

We all know that in the clinical treatment of diseases, the combination of drugs for the treatment of causes and drugs for symptomatic treatment is much better than the actual use of drugs for the treatment of causes alone. So for doxycycline, an antibacterial and anti-mycoplasma agent, its combination with the antipyretic, analgesic and anti-inflammatory drug carbapyrine calcium powder is a more reasonable compatibility.

However, in practice, those who have used this compatibility program to treat the corresponding disease are either praised for the use of this program, or they are deeply impressed by the compatibility. It is not said that doxycycline and carbapyrine calcium can be pharmacologically, but why do these two completely different "use results evaluation"?

The reason is that although the principle of compatibility of carbapyrine calcium and doxycycline is scientific and reasonable. However, since doxycycline belongs to the tetracycline class of antibiotics, and carbapyrine calcium is compatible with tetracycline antibiotics "when mixed together to drink water for chickens", calcium ions in carbapyrine calcium will be free in water and react with doxycycline in the same water.

The result of the reaction of the two drugs, on the surface, is turbidity, precipitation and discoloration of the mixed solution of the two drugs, which is manifested as a chemical reaction phenomenon. Even abandon the effect for the time being, with this compatibility will also plug the water line. Since then, the drug not only did not play a curative effect, but also produced a new problem of "drug water blocking line", but increased a lot of costs.

The effect is not good, mainly because doxycycline and carbapyrine calcium dissolved in water after the reaction of a large number of free calcium ions, to produce a large number of new insoluble calcium salts and calcium complexes, resulting in a new problem of plugging the water line. Not only that, these newly produced compounds basically have no pharmacological antibacterial activity, resulting in drug treatment failure.

So, since this is the case, why do some people say that the effect of use is good?

This is because some people use this combination, one drinking water and one mixing material are used at the same time, thus avoiding the reaction of the two drugs in water. Others were even more straightforward, giving doxycycline and carbapyrine calcium together. Although these two methods of administration are more troublesome, it avoids the "problem of long-term reaction in water" of doxycycline and carbapyrine calcium.

So, in addition, there is also a situation that carbapyrine calcium and doxycycline are soluble in water, and they are easy to react and reduce the therapeutic effect when they meet directly with each other, and will also block the water line and increase the cost of new farming. If the preparation technology innovation means to wear a layer of clothing to the outside of carbapyrine calcium, not only to avoid the stimulation of carbapyrine calcium drugs on the gastrointestinal tract, but also to avoid the stimulation of carbapyrine calcium on the upper digestive tract.

This is the use of veterinary drug preparations with a high level of technology, compared with those preparations seem particularly cheap apis, may be a lot of money. However, the defects of pharmaceutical technology for drug solubility in water, as well as the challenging problems of compounding with other drugs, have been broken through through pharmaceutical technology innovation. Of course, the technological breakthrough and application of this preparation reflects the value of veterinary drug preparations compared with the original powder.