The usege technology and drug combination about doxycycline

Doxycycline, also known as doxycycline hydrochloride, also known as deoxytetracycline, belongs to the tetracycline class of antibiotics, which has a broad spectrum of antibacterial activity but is 2-10 higher than oxytetracycline. This is a common aquaculture drug, the frequency of use is very high, often used in the treatment of avian mycoplasma, swine respiratory diseases, especially for mycoplasma and bacterial mixed treatment effect is also very good. But it is such a common drug, many farmers do not understand, will not use! So the bottom line is multiple bacteria, four body diseases, and one worm.

Commonly used in these 7 cases:

1, bacterial disease, used in respiratory tract, such as pleuropneumonia, swine lung disease and other diseases, doxycycline + flufenicol + fever drug effect is good;

2, actinomycetes, that is, pigs can grow in various positions of the pus, in addition to streptococcus pyogenes, there is another situation is caused by actinomycetes, generally doxycycline effect is better;

3, common, "body" disease; Mycoplasma is also wheezing disease, doxycycline + flufenicol (mycoplasma net) effect is good;

4, chlamydia, the first is sow abortion, fetal pearl-like to consider, with doxycin treatment effect is better; The second kind of conjunctivitis, red eyes use tetracycline eye drops eye effect is better;

5, spirochaeta (swine dysentery, etc.), Rickettsia with less, not much to say;

6, the worm, is the blood protozoa, that is, we often say with red body and other diseases, doxycycline administration effect is better;

7, oxytetracycline is generally used in the prevention and treatment of sows, the harm is less and the effect is more moderate; Doxycycline is often used in lactating piglets after seven days, yellow with white, white with gray such feces; Fat pigs in the dog days, often have a fever rebound, repeated.

How can doxycycline be used to multiply the effect?

Flufenicol + doxycycline (doxycycline)

It's a very common formula, but do you know the one that doubles the effect? So what is the doxycycline ratio? Doxycycline and flufenicol the correct ratio is 2:1, we must follow this ratio to dispense medicine, otherwise the effect is not out.

Specific algorithm: First calculate the dosage of doxycycline, and then divide the dosage of doxycycline by 2, and get the dosage of flufenicol.

Specific dosage: In the case of treatment, 1g doxycycline is mixed with 6-8 kilograms of water, according to this amount even if the dosage, otherwise the effect is very poor. Why do we need more here? Here to give everyone a general knowledge, all tetracycline drugs in the process of use to increase the amount of use.

Note:

1. The toxicity of this product is small in this class of drugs, generally will not cause bacterial imbalance, but it can not be used in large doses for a long time;

2, equine animals are sensitive to this product, intravenous injection can cause poisoning or death, should not be used intravenously.

3, pay attention to doxycycline injection is more painful, pay attention to stress;

Why doxycycline is the first choice to treat the Eperythrozoonosis

According to foreign data, because the biological characteristics of eperythrozoon were inconsistent with other conventional bacteria, it was initially classified as a member of the Microsporidium family (1974). It was later classified as Rickettsia. However, because it is not an obligate parasite within the cell, the individual is small, has no cell wall, is resistant, and is sensitive to tetracycline. Later, it was found that the genetic sequence of the pathogen was very similar to Rickettsia, but it was closer to the sequence of mycoplasma. In recent years, the name Haemophilus suis has been widely used in Western countries, because doxycycline has a better effect on rickettsial and mycoplasma disease, and it may be that tetracycline drugs are more effective in the treatment of porcine eperythrozoonosis. In the course of treating eperythrozoonosis with tetracycline, we found that doxycycline in tetracycline had the best effect.

Doxycycline combined with carbapyrine calcium for treatment of respiratory diseases in livestock and poultry

Doxycycline is a tetracycline broad-spectrum antibacterial and antimycoplasma drug with acidic aqueous solution and good oral absorption. It is easily soluble in water, easy to be affected by metal ions in water and form a complex, forming a red solution and reducing the efficacy of drugs.

Therefore, in the selection of the drug, it is very important to choose products with preparation technology and ensure good stability.

In veterinary treatment of livestock and poultry, doxycycline is mainly used to treat respiratory tract infections caused by sensitive bacteria and mycoplasma. Among many pathogenic microorganisms, doxycycline is especially effective against trachea and bronchitis caused by gram-negative bacteria and mycoplasma.

The main reasons for the better effect of doxycycline on trachea and bronchitis in livestock and poultry are its wide antibacterial spectrum and strong antibacterial effect. In addition to its good effect on Gram-positive and Gram-negative bacteria, it can inhibit mycoplasma respirans and Rickettsiae pathogens that are resistant to or insensitive to other drugs.

Moreover, doxycycline is absorbed faster after oral administration, and the maximum effect can be achieved about 3h, and the maintenance time in the body is long. Third, doxycycline has certain antitussive, expectorant and wheezing effects, which have been confirmed by animal experiments and are not the characteristics of other antibiotics.

These unique advantages of doxycycline mentioned above, as well as the fact that it maintains an effective effect in livestock and poultry at a longer blood concentration than the currently commonly used respiratory drugs, further explain "why doxycycline is more effective in the treatment of trachea and bronchitis in livestock and poultry."

Carbapyrine calcium is an antipyretic and anti-inflammatory agent. It is a chelate of calcium acetylsalicylate (calcium salt of aspirin) and urea. Soluble in water, aqueous solution is acidic. This product has significant antipyretic, analgesic, anti-inflammatory effects, rapid oral absorption, rapid onset, high bioavailability. It can be widely combined with plasma proteins and rapidly distributed to whole body tissues and organs such as trachea, bronchus and lungs.

Carbapyrine calcium can inhibit the reaction of antigen and antibody conjugate in allergy, improve the clinical symptoms such as redness, swelling, heat and pain in the process of inflammation, and reduce inflammatory exudation.

In the process of inhibiting the pathological reaction of the body, carbapyrine calcium can reduce inflammatory exudation by inhibiting the reaction of antigen and antibody conjugate in allergy, and inhibit the production of endotoxin and the inflammation and swelling caused by the increase of plasma protein exudation of small veins.

According to the physicochemical and pharmacological characteristics of the above two drugs, doxycycline is better than doxycycline alone in the treatment of respiratory diseases of livestock and poultry by combining and prescribing doxycycline with calcium carbapyrine.

In terms of rapid control of pathological deterioration and effective treatment, the prescription can enhance the antibacterial and anti-mycoplasma effects of doxycycline, and the synergistic administration of the two drugs can significantly improve the therapeutic effect of doxycycline on respiratory diseases in livestock and poultry.