Advantages of colistin sulfate and combined use techniques

Combination medication is an important means to improve the level of drug therapy, especially in the clinical emergence of a single drug can not control the mixed infection and the etiology of unknown serious infection, the need to give combined medication to the chickens.

1. What are the advantages of colistin sulfate?

Colistin sulfate - acid antibiotics, not only low concentration bacteriostasis, high concentration bactericidal, but also promote digestion, aid growth, improve feed utilization, reduce feed to egg ratio.

2. When poultry has what disease, can colistin sulfate be used?

When chickens have intestinal diseases such as necrotizing enteritis and enterotoxic syndrome, they are treated with colistin sulfate. At this time, the sick chicken will develop intractable diarrhea, pull red stool or black stool, stool is not formed and contains undigested feed particles; Autopsy of dead chickens found that the intestinal wall was thinner, the mucosa was detached, the intestinal wall was dark brown or the intestinal tract was full of blood samples.

3. How can the combination of drugs work best?

In the process of combining the two drugs, three different results will be produced, which are synergistic, additive and antagonistic. The so-called drug synergy is the enhancement of the total efficacy after the combination of two drugs, that is, 1+1>2, which is also the purpose of combined drug use to be achieved. How to use colistin sulfate synergistically in chicken farm? Veterinarian: 3 combinations, double the potency

(1) Colistin sulfate + Flufenicol sulfate colistin increases the permeability of cell membrane, is conducive to the entry of flufenicol into bacterial cells, further blocking the synthesis of bacterial proteins, the combination of the two drugs, internal and external combination, synergistic sterilization, not only enhances the bactericidal effect, but also expands the antibacterial spectrum, that is, 1+1>2.

For chicken Escherichia coli, Salmonella, dysentery bacillus, shigella, Clostridium percapsulatus caused by chicken white dysentery - anal, necrotizing enteritis - overfeeding and other intestinal bacterial infections doubled the therapeutic effect, especially has an efficient killing effect on intestinal bacteria.

(2) Colistin sulfate + amoxicillin compound amoxicillin and colistin sulfate, respectively, belong to the breeding period fungicide (class I) and quiescent period fungicide (Class II), the two drugs used together, cooperate with each other, not only reduce the generation of resistance, but also improve the bactericidal effect, that is, 1+1>2. The treatment effect of chicken enteric bacteria mixed infection caused by Escherichia coli, Salmonella and dysentery bacillus was doubled.